Globally significant results from the TOPGEAR study on which TROG collaborated have recently been reported and provide practice-changing evidence about preoperative chemoradiotherapy for gastric and gastro-oesophageal junction cancers. The findings were announced at the European Society for Medical Oncology (ESMO) Congress in Barcelona and published simultaneously in the New England Journal of Medicine, providing a high quality answer to a long-standing question in gastro-oesophageal cancer.